Genomic Resolution of DLX-Orchestrated Transcriptional Circuits Driving Development of Forebrain GABAergic Neurons

Summary: DLX transcription factors (TFs) are master regulators of the developing vertebrate brain, driving forebrain GABAergic neuronal differentiation.Ablation of Dlx1&2 alters expression of genes that are critical for forebrain GABAergic development.We integrated epigenomic and transcriptomic analyses, complemented with in situ hybridization (ISH

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Potential bias in ophthalmic pharmaceutical clinical trials

Paul VarnerJohn J Pershing Veterans’ Administration Medical Center, Poplar Bluff, Missouri, USAAbstract: To make clinicians argan oil pure purple aware of potential sources of error in ophthalmic pharmaceutical clinical trials that can lead to erroneous interpretation of results, a critical review of the study design of various pharmaceut

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